Fu Xi was born on the lower-middle reaches of the Yellow River in a place called Chengji (possibly modern Lantian, Shaanxi or Tianshui, Gansu).

According to legend the land was swept by a great flood and only Fuxi and his sister Nüwa survived. They retired to Kunlun Mountain where they prayed for a sign from the Emperor of Heaven. The divine being approved their union and the siblings set about procreating the human race. It was said that in order to speed up the procreation of humans, Fu Xi and Nüwa find an additional way by using clay to create human figures, and with the power divine being entrusted to them, they made the clay figures to come alive. Fu Xi then came to rule over his descendents although reports of his long reign vary between sources from 115 years (BCE 2852-2737) to 116 years (BCE 2952-2836).

He lived for 197 years altogether and died at a place called Chen (modern Huaiyang, Henan)